Givaudan Active Beauty introduces PrimalHyal™ 300

For years, Givaudan Active Beauty has been perfecting the science behind hyaluronic acid. Building on this long-standing expertise, PrimalHyal™ 300, a medium molecular weight hyaluronic acid derived from biotechnology, acts as the ‘healer’ of the PrimalHyal™ range and represents a go-to active ingredient for fast skin recovery and repair.

Designed as the skin healing accelerator, PrimalHyal™ 300 strengthens the skin’s natural defence system and helps accelerate recovery when the barrier is compromised, particularly in post-procedure care.

Developed in the Champagne region of France through sustainable innovation, PrimalHyal™ 300 is produced in a biorefinery rooted in the principles of the circular economy, reflecting Givaudan Active Beauty’s commitment to responsible innovation and performance-driven skin science.

With aesthetic treatments having increased fivefold over the last 30 years¹, understanding and supporting this mechanism has never been more critical. Recent scientific discoveries² have highlighted bleomycin hydrolase as a key enzyme involved in hydration, wound healing and epidermal barrier integrity. When the skin barrier is disrupted, fast and coordinated repair becomes essential. 

PrimalHyal™ 300 activates skin renewal by boosting bleomycin hydrolase levels by 79%, helping the skin remain hydrated while accelerating its natural recovery.

In ex vivo explant models, even after harsh chemical peeling, PrimalHyal™ 300 helped restore skin barrier strength in just a few days and significantly increased ceramide content (up to 15-fold versus control) – the natural ‘cement’ that binds skin cells together.

These effects were confirmed by clinical studies conducted on women who underwent deep fractional CO₂ laser treatments:

• After three days: visible improvement in hydration
• After one week: substantial reduction in redness and irritation
• Overall: smoother, calmer and more resilient skin

“Our skin is our first line of defence – a complex and dynamic structure that must repair itself effectively when compromised. PrimalHyal™ 300 is the result of years of research into how hyaluronic acid can support the skin’s natural repair and cell reconnection processes. By specifically reactivating bleomycin hydrolase production, it helps the skin heal better, faster and more effectively.”

Amandine Scandolera, Head of Biological Evaluation at Givaudan Active Beauty

As aesthetic treatments continue to rise in popularity, PrimalHyal™ 300 represents a science-backed breakthrough in skin regeneration, offering a new era in skin hydration, accelerated recovery and skin barrier restoration.

To learn more about our new ingredient and its inspirational concept, S3D® SkinXpert, we invite you to visit us on 14-16 April 2026 at our booth #3F110, 3F130 at in-cosmetics Global, taking place in Paris, France. Or connect to uxbeauty.givaudan.com, our digital platform dedicated to cosmetic ingredients.

1. Noël B., Dermatologie esthétique et correctrice : applications cliniques et rôle social, Revue Médicale Suisse, 2009. DOI: 10.53738/REVMED.2009.5.200.0895.

2. Riise, R., Odqvist, L., Mattsson, J. et al. Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes. Sci Rep 9, 20407 (2019). https://doi.org/10.1038/s41598-019-56667-6.

About Givaudan
Givaudan is a global leader in Fragrance & Beauty and Taste & Wellbeing. We celebrate the beauty of human experience by creating for happier, healthier lives with love for nature. Together with our customers we deliver food experiences, craft inspired fragrances and develop beauty and wellbeing solutions that make people look and feel good. In 2025, Givaudan employed over 17,500 people worldwide and achieved CHF 7.5 billion in sales with a free cash flow of 14.1%. With a heritage that stretches back over 250 years, we are committed to driving long-term, sustainable growth by improving people’s health and happiness and increasing our positive impact on nature. This is Givaudan. Human by nature. Discover more at: www.givaudan.com.

About Givaudan Fragrance & Beauty
Givaudan Fragrance & Beauty crafts inspired fragrances to perfume lives and memories, and develops innovative beauty and wellbeing solutions that make people look and feel good all over the world. Nature is both our responsibility and our most precious muse. We are just as committed to sustainability as we are to creating innovative products that satisfy consumer needs and anticipate their desires. With a collaborative approach that favours co-creation, we have built a diverse portfolio across personal care, fabric care, hygiene, home care, fine fragrances, and beauty, reflecting our multidisciplinary expertise. This is Givaudan. Human by nature. Learn more at www.givaudan.com/fragrance-beauty.

About Givaudan Active Beauty
Givaudan Active Beauty crafts avant-garde cosmetic actives and high-end specialties that make people look and feel good. We bring nature’s most precious gifts to the art of personal care in the form of biotech & botanical high-performing molecules, delighting consumers. Our extensive portfolio of award-winning skin & hair ingredients spans a variety of benefits for human beauty: from well-ageing and self-tanners to radiance, microbiome-friendly, soothers, hydrators, and more. Backed by solid scientific recognition and consumers’ awareness, we remain at the cutting edge of this rapidly expanding market to deliver sustainable solutions supporting the growth of our customers. This is Givaudan. Human by nature. Learn more at www.givaudan.com/active-beauty.

For further information please contact
Agathe Parent, Active Beauty Communications    
E agathe.parent@givaudan.com