Givaudan Active Beauty unveils PrimalHyal™ NeuroYouth

Givaudan Active Beauty presents PrimalHyal™ NeuroYouth, an innovative complex based on low molecular weight hyaluronic acid and amino acids designed to address a recently identified skin ageing pathway defined by Givaudan Active Beauty as ‘Neuro Skin Ageing’. By restoring nerve fibre function and neuronal communication, PrimalHyal™ NeuroYouth opens up a new frontier in skin health and well-ageing, where sensory perception becomes a new dimension of youthful-looking skin.

Beyond its protective barrier function, the skin is a living sensory network. With age, the skin’s nerve fibres become fewer, shorter and less functional, leading to decreased sensory perception, but also to impaired cellular communication and accelerated skin ageing. This process has been highlighted by Givaudan Active Beauty’s research and recognised among the IFSCC 2025 scientific contributions.

To address this new longevity pathway, Givaudan Active Beauty has leveraged the skin’s natural affinity for very low molecular weight hyaluronic acid as a vector to optimise the delivery of selected amino acids within the skin. Inspired by microneedling delivery concepts described in cosmetic and pharmaceutical literatures, PrimalHyal™ NeuroYouth is a unique hyaluronic acid-base amino-acid complex designed to enhance skin bioavailability and the biological relevance of the amino acids.

Clinical studies conducted on more than 120 volunteers demonstrate that PrimalHyal™ NeuroYouth delivers visible and measurable anti-ageing benefits, including: 

• Apparent skin age reduced by over 5 years
• Visible reduction in wrinkles and fine lines
• Improvement in dermal tension and skin firmness
• Touch perception restored by up to 30 years
• Perceivable improvement of pleasant sensations

PrimalHyal™ NeuroYouth reverses the neuro-ageing pathway, enabling neuronal growth and density-related parameters (with a +28% increase in nerve fibre count and a +29% increase in their length), enhancing neuronal communication pathways through NGF-like activity, reactivating neuronal mitochondria energetic efficiency. By supporting the skin’s neuro-sensory environment and helping to preserve skin homeostasis, PrimalHyal™ NeuroYouth contributes to stronger-looking, healthier and more comfortable skin, while enhancing the perceived capacity of the skin to sense and interact with its environment.

“Beyond aesthetics, PrimalHyal™ NeuroYouth redefines skin ageing from a skin health perspective. By addressing ‘Neuro Skin Ageing’, it offers new perspectives for the positioning of silver age, pre-juvenation and skin resilience concepts, where neurological health becomes a key pillar of youthful skin.”

Romain Reynaud, R&D Director at Givaudan Active Beauty

To learn more about our new ingredient and its inspirational concept, S3D® ReSense, Delight Body Lotion and S3D® ReSense, Youth-Awakening Serum, we invite you to visit us on 14-16 April 2026 at our booth #3F110, 3F130 at in-cosmetics Global, taking place in Paris, France. Or connect to uxbeauty.givaudan.com, our digital platform dedicated to cosmetic ingredients.

About Givaudan
Givaudan is a global leader in Fragrance & Beauty and Taste & Wellbeing. We celebrate the beauty of human experience by creating for happier, healthier lives with love for nature. Together with our customers we deliver food experiences, craft inspired fragrances and develop beauty and wellbeing solutions that make people look and feel good. In 2025, Givaudan employed over 17,500 people worldwide and achieved CHF 7.5 billion in sales with a free cash flow of 14.1%. With a heritage that stretches back over 250 years, we are committed to driving long-term, sustainable growth by improving people’s health and happiness and increasing our positive impact on nature. This is Givaudan. Human by nature. Discover more at www.givaudan.com.

About Givaudan Fragrance & Beauty
Givaudan Fragrance & Beauty crafts inspired fragrances to perfume lives and memories, and develops innovative beauty and wellbeing solutions that make people look and feel good all over the world. Nature is both our responsibility and our most precious muse. We are just as committed to sustainability as we are to creating innovative products that satisfy consumer needs and anticipate their desires. With a collaborative approach that favours co-creation, we have built a diverse portfolio across personal care, fabric care, hygiene, home care, fine fragrances, and beauty, reflecting our multidisciplinary expertise. This is Givaudan. Human by nature. Learn more at www.givaudan.com/fragrance-beauty.

About Givaudan Active Beauty
Givaudan Active Beauty crafts avant-garde cosmetic actives and high-end specialties that make people look and feel good. We bring nature’s most precious gifts to the art of personal care in the form of biotech & botanical high-performing molecules, delighting consumers. Our extensive portfolio of award-winning skin & hair ingredients spans a variety of benefits for human beauty: from well-ageing and self-tanners to radiance, microbiome-friendly, soothers, hydrators, and more. Backed by solid scientific recognition and consumers’ awareness, we remain at the cutting edge of this rapidly expanding market to deliver sustainable solutions supporting the growth of our customers. This is Givaudan. Human by nature. Learn more at www.givaudan.com/fragrance-beauty/active-beauty.

For further information please contact
Agathe Parent, Active Beauty Communication
E agathe.parent@givaudan.com